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JTV-519 fumarate
CAS No. 1883549-36-7
JTV-519 fumarate( K201 | JTV519 )
Catalog No. M12934 CAS No. 1883549-36-7
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameJTV-519 fumarate
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NoteResearch use only, not for human use.
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Brief DescriptionJTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
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DescriptionJTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).Heart Arrhythmia Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsK201 | JTV519
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1883549-36-7
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Formula Weight540.675
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Molecular FormulaC29H36N2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Darcy YL, et al. Mol Pharmacol. 2016 Aug;90(2):106-15.
2. Inagaki K, et al. Circulation. 2000 Feb 22;101(7):797-804.
3. Ito K, et al. Br J Pharmacol. 2000 Jun;130(4):767-76.
4. Nakaya H, et al. Br J Pharmacol. 2000 Dec;131(7):1363-72.
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